Mouse Fen1 cDNA Clone(BC010203)

Name: Mouse Fen1 cDNA Clone(BC010203)
SKU: CDFG022325
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFG022325

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Product Information

Gene Information

Cat. No.	CDFG022325
Product Type	cDNA clone
Gene Abbr	Fen1
Species	Mouse
ORF Size	1143bp
Size	10 ug
Vector	pCMV6Entry

Target Gene

FEN1

Background

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]

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