Mouse Etv1 cDNA Clone(BC005645)

Name: Mouse Etv1 cDNA Clone(BC005645)
SKU: CDFG022246
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFG022246

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Product Information

Gene Information

Cat. No.	CDFG022246
Product Type	cDNA clone
Gene Abbr	Etv1
Species	Mouse
ORF Size	1434bp
Size	10 ug
Vector	pCMV6Entry

Target Gene

ETV1

Background

This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]

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