Mouse Coch cDNA Clone(BC045137)

Name: Mouse Coch cDNA Clone(BC045137)
SKU: CDFG022045
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFG022045

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Product Information

Gene Information

Cat. No.	CDFG022045
Product Type	cDNA clone
Gene Abbr	Coch
Species	Mouse
ORF Size	2480bp
Size	10 ug
Vector	pCMV6-Kan/Neo

Target Gene

COCH

Background

The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq, Oct 2008]

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