Human Smarca4 adenoviral particles

Name: Human Smarca4 adenoviral particles
SKU: AD15133Z
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : AD15133Z

Storage : -80℃ Shipping : Frozen on dry ice

Titer: Size:

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Virus Particles Information

Quality Control

Gene Information

Cat. No.	AD15133Z
Description	Adenovirus with ORF of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), transcript variant 6.
Gene	Smarca4
Species	Human
Titer	Varies lot by lot, for example, ≥1x10^10 IFU/mL, ≥1x10^11 IFU/mL, ≥1x10^11 VP/mL etc.
Size	Varies lot by lot, for example, 100 ul, 500 ul, 1 mL etc.
Storage	Store at -80℃. Avoid multiple freeze/thaw cycles.
Shipping	Frozen on dry ice

Summary	Creative Biogene ensures high-quality adenovirus particles by optimizing and standardizing production protocols and performing stringent quality control (QC). The specific QC experiments performed vary between adenovirus particle lots.
Endotoxin	Endotoxins, primarily derived from Gram-negative bacteria, can trigger adverse immune responses. Endotoxin contamination is a significant concern in adenovirus production, especially for applications in animal studies and gene therapy. Creative Biogene utilizes rigorous endotoxin detection methods to monitor the endotoxin level in our produced adenovirus particles to ensure regulatory compliance.
Sterility	Creative Biogene ensures that adenovirus products are free of any bacterial, fungal and other microbial contamination.
Ad5 E1 Detection	All Creative Biogene adenoviruses are PCR tested to ensure that there are no detectable E1 sequences in the particles, which could be from revertants or external E1 contamination.
RCA Assays	Adenovirus products originating at Creative Biogene are guaranteed to have undetectable replication-competent adenovirus (RCA). This quality control measure is important because there is always the possibility of wild-type contamination due to revertants or environmental sources.
PFU Titering	All purified adenovirus preparations are tested for infectious titer. Creative Biogene's PFU test takes a few days longer but counts true plaques in HEK cells rather than estimating PFU titers via IHC staining or TCI50 of infected cells.

Gene Name	SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [ Homo sapiens ]
Gene Symbol	SMARCA4
Synonyms	BRG1; SNF2; SWI2; MRD16; RTPS2; BAF190; SNF2L4; SNF2LB; hSNF2b; BAF190A
GeneID	6597
Uni ProtID	A7E2E1
mRNA Refseq	NM_001128844.1
Protein Refseq	NP_001122316.1
Chromosome Location	19p13.2
Function	ATP binding; DNA-dependent ATPase activity; RNA polymerase II regulatory region sequence-specific DNA binding; Tat protein binding; androgen receptor binding; chromatin binding; helicase activity; histone acetyl-lysine binding; p53 binding; protein N-terminus binding; protein binding; transcription coactivator activity; transcription coactivator activity; transcription corepressor activity;
Pathway	Direct p53 effectors, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem; Integrated Breast Cancer Pathway, organism-specific biosystem; Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem; Regulation of retinoblastoma protein, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem;
MIM	603254

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