Human SCARB1 adenoviral particles

The SCARB1 gene (scavenger receptor class B member 1) encodes a cell surface glycoprotein that plays a key role in lipid metabolism and reverse cholesterol transport. As a high-density lipoprotein (HDL) receptor, SCARB1 promotes the selective uptake of cholesterol esters from HDL particles into cells, particularly in the liver, steroidogenic tissues, and endothelial cells. In addition to lipid metabolism, SCARB1 is involved in a variety of physiological processes, including regulation of immune responses, pathogen recognition, and vitamin E transport. SCARB1 gene dysregulation has been associated with atherosclerosis, cardiovascular disease, and metabolic disorders, making it a key target for therapeutic and research applications. Its versatility highlights its importance in basic science and clinical research.

Human SCARB1 adenoviral particles are genetically engineered viral vectors designed to deliver the SCARB1 gene to target cells for functional studies or therapeutic purposes. These vectors take advantage of the high transduction efficiency and broad tropism of adenoviruses to achieve stable gene expression in both dividing and non-dividing cells. To ensure safety, the adenoviral backbone is modified, typically by deleting essential viral replication genes (E1/E3 regions) and replacing them with human SCARB1 cDNA regulated by a strong promoter. Such vectors are valuable tools for in vitro and in vivo studies of the role of SCARB1 in lipid homeostasis, cell signaling, or disease mechanisms.