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Human Rad50 Knockdown Cell Line-HeLa

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Cat.No.
CSC-RK0012
Background
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region this similar protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Ship
Dry ice
Gene Information
Official Symbol
RAD50
Synonyms
RAD50; RAD50 homolog (S. cerevisiae); RAD50 (S. cerevisiae) homolog; DNA repair protein RAD50; hRad50; RAD50 2; NBSLD; RAD502;
Gene ID
MIM
UniProt ID
Q92878
Chromosome Location
5q23-q31
Pathway
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; DNA Repair, organism-specific biosystem; Double-Strand Break Repair, organism-specific biosystem; Homologous Recombination Repair, organism-specific biosystem; Homologous recombination, organism-specific biosystem;
Function
contributes_to 3-5 exonuclease activity; ATP binding; contributes_to ATP-dependent DNA helicase activity; DNA binding; hydrolase activity; metal ion binding; nuclease activity; nucleotide binding; protein binding; protein binding, bridging; contributes_to single-stranded DNA specific endodeoxyribonuclease activity; zinc ion binding;

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