Human Rad50 Knockdown Cell Line-HeLa

Name: Human Rad50 Knockdown Cell Line-HeLa
SKU: CSC-RK0012
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0012

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0012
Background	This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region this similar protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.
Target Gene	RAD50
Abbr	HeLa-HuRad50 Knockdown
Alias	RAD50, hRad50, RAD50 2, NBSLD, RAD502
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	RAD50 RAD50 homolog (S. cerevisiae) [ Homo sapiens ]
Gene Symbol	RAD50
Synonyms	NBSLD; RAD502; hRad50
Gene ID	10111
Uni Prot ID	A5D6Y3
m RNA Refseq	NM_005732.3
Protein Refseq	NP_005723.2
Chromosome Location	5q31
Function	contributes_to 3-5 exonuclease activity; ATP binding; contributes_to ATP-dependent DNA helicase activity; DNA binding; protein binding; protein binding, bridging; contributes_to single-stranded DNA specific endodeoxyribonuclease activity; zinc ion binding;
Pathway	Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; DNA Repair, organism-specific biosystem; DNA damage response, organism-specific biosystem; Double-Strand Break Repair, organism-specific biosystem; Homologous Recombination Repair, organism-specific biosystem;
MIM	604040

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