Human Plcg1 adenoviral particles

Name: Human Plcg1 adenoviral particles
SKU: AD12394Z
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : AD12394Z

Storage : -80℃ Shipping : Frozen on dry ice

Titer: Size:

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Virus Particles Information

Quality Control

Gene Information

Cat. No.	AD12394Z
Description	Adenovirus with ORF of phospholipase C, gamma 1 (PLCG1), transcript variant 1.
Gene	Plcg1
Species	Human
Titer	Varies lot by lot, for example, ≥1x10^10 IFU/mL, ≥1x10^11 IFU/mL, ≥1x10^11 VP/mL etc.
Size	Varies lot by lot, for example, 100 ul, 500 ul, 1 mL etc.
Storage	Store at -80℃. Avoid multiple freeze/thaw cycles.
Shipping	Frozen on dry ice

Summary	Creative Biogene ensures high-quality adenovirus particles by optimizing and standardizing production protocols and performing stringent quality control (QC). The specific QC experiments performed vary between adenovirus particle lots.
Endotoxin	Endotoxins, primarily derived from Gram-negative bacteria, can trigger adverse immune responses. Endotoxin contamination is a significant concern in adenovirus production, especially for applications in animal studies and gene therapy. Creative Biogene utilizes rigorous endotoxin detection methods to monitor the endotoxin level in our produced adenovirus particles to ensure regulatory compliance.
Sterility	Creative Biogene ensures that adenovirus products are free of any bacterial, fungal and other microbial contamination.
Ad5 E1 Detection	All Creative Biogene adenoviruses are PCR tested to ensure that there are no detectable E1 sequences in the particles, which could be from revertants or external E1 contamination.
RCA Assays	Adenovirus products originating at Creative Biogene are guaranteed to have undetectable replication-competent adenovirus (RCA). This quality control measure is important because there is always the possibility of wild-type contamination due to revertants or environmental sources.
PFU Titering	All purified adenovirus preparations are tested for infectious titer. Creative Biogene's PFU test takes a few days longer but counts true plaques in HEK cells rather than estimating PFU titers via IHC staining or TCI50 of infected cells.

Gene Name	PLCG1 phospholipase C, gamma 1 [ Homo sapiens ]
Gene Symbol	PLCG1
Synonyms	PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1
Gene Description	phospholipase C, gamma 1
Gene ID	5335
Uni Prot ID	A2A284
m RNA Refseq	NM_002660.2
Protein Refseq	NP_002651.2
Chromosome Location	20q12-q13.1
Function	calcium ion binding; glutamate receptor binding; insulin receptor binding; neurotrophin TRKA receptor binding; phosphatidylinositol phospholipase C activity; phosphatidylinositol phospholipase C activity; phospholipase C activity; phospholipid binding; phosphoprotein binding; protein binding; receptor signaling protein activity; receptor tyrosine kinase binding;
Pathway	Adaptive Immune System, organism-specific biosystem; Angiogenesis, organism-specific biosystem; Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem; Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Axon guidance, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem;
MIM	172420

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