Human PPP1CA adenoviral particles

The PPP1CA gene encodes protein phosphatase 1 catalytic subunit alpha (PP1α), a key serine/threonine phosphatase involved in regulating multiple cellular processes including cell cycle progression, metabolism, and signal transduction. As one of the major isoforms of PP1, PP1α is able to dephosphorylate target proteins to regulate their activity, thereby maintaining cellular homeostasis. Dysregulation of PPP1CA has been implicated in a variety of diseases, such as cancer, neurodegenerative diseases, and cardiovascular diseases, highlighting its critical role in maintaining physiological balance. Research on PPP1CA has often focused on understanding its regulatory mechanisms and its interactions, making it a key target for therapeutic and functional studies.

Human PPP1CA Adenoviral Particles are genetically engineered recombinant adenovirus designed to deliver the PPP1CA gene into mammalian cells for overexpression studies. These viral particles take advantage of the high transduction efficiency and broad tropism of adenoviral vectors to ensure stable gene delivery in both dividing and non-dividing cells. These viral particles are replication-defective, enhancing safety for in vitro and in vivo applications. They are ideal for studying the functional role of PP1α, pathway analysis, or rescuing phenotypes in PPP1CA-deficient models. They are purified and titrated to ensure consistent performance, providing researchers with a reliable tool for gene therapy exploration, mechanistic studies, or drug screening.