Human NPR3 Knockout Cell Line-HeLa

The natriuretic peptide receptor 3 (NPR3) gene, also known as NPRC, is an important component of the natriuretic peptide receptor family and plays an important role in cardiovascular homeostasis. The NPR3 gene encodes the NPR-C receptor, a cell surface protein involved in the clearance of circulating natriuretic peptides (NPs), thereby regulating their biological effects. Unlike other natriuretic peptide receptors (NPR-A and NPR-B), which are associated with guanylate cyclase activity and cGMP production, NPR-C primarily functions by removing active peptides and regulating their concentrations in the bloodstream.

The structure of NPR3 includes an extracellular ligand-binding domain, a single transmembrane domain, and a short intracellular domain. The role of this receptor in cardiovascular health extends to influencing vasodilation, diuresis, and sodium excretion. In addition to its classical roles, recent studies have also delved into the function of NPR3 in adipose tissue, where it affects the adipokine network and energy metabolism, suggesting a possible involvement in metabolic disorders. Mutations or dysregulation of the NPR3 gene can lead to various pathological conditions. Reduced NPR3 expression has been associated with hypertension, heart failure, and other cardiovascular diseases, highlighting its potential as a therapeutic target.