Human NEDD4 adenoviral particles

Name: Human NEDD4 adenoviral particles
SKU: AD10671Z
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : AD10671Z

Storage : -80℃ Shipping : Frozen on dry ice

Titer: Size:

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Virus Particles Information

Quality Control

Gene Information

Cat. No.	AD10671Z
Description	Adenovirus with ORF of neural precursor cell expressed, developmentally down-regulated 4 (NEDD4), transcript variant 2.
Gene	NEDD4
Species	Human
Titer	Varies lot by lot, for example, ≥1x10^10 IFU/mL, ≥1x10^11 IFU/mL, ≥1x10^11 VP/mL etc.
Size	Varies lot by lot, for example, 100 ul, 500 ul, 1 mL etc.
Storage	Store at -80℃. Avoid multiple freeze/thaw cycles.
Shipping	Frozen on dry ice

Summary	Creative Biogene ensures high-quality adenovirus particles by optimizing and standardizing production protocols and performing stringent quality control (QC). The specific QC experiments performed vary between adenovirus particle lots.
Endotoxin	Endotoxins, primarily derived from Gram-negative bacteria, can trigger adverse immune responses. Endotoxin contamination is a significant concern in adenovirus production, especially for applications in animal studies and gene therapy. Creative Biogene utilizes rigorous endotoxin detection methods to monitor the endotoxin level in our produced adenovirus particles to ensure regulatory compliance.
Sterility	Creative Biogene ensures that adenovirus products are free of any bacterial, fungal and other microbial contamination.
Ad5 E1 Detection	All Creative Biogene adenoviruses are PCR tested to ensure that there are no detectable E1 sequences in the particles, which could be from revertants or external E1 contamination.
RCA Assays	Adenovirus products originating at Creative Biogene are guaranteed to have undetectable replication-competent adenovirus (RCA). This quality control measure is important because there is always the possibility of wild-type contamination due to revertants or environmental sources.
PFU Titering	All purified adenovirus preparations are tested for infectious titer. Creative Biogene's PFU test takes a few days longer but counts true plaques in HEK cells rather than estimating PFU titers via IHC staining or TCI50 of infected cells.

Gene Name	NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [ Homo sapiens ]
Gene Symbol	NEDD4
Synonyms	RPF1; NEDD4-1
Gene ID	4734
Uni Prot ID	P46934
m RNA Refseq	NM_006154.2
Protein Refseq	NP_006145.2
Chromosome Location	15q
Function	RNA polymerase binding; beta-2 adrenergic receptor binding; phosphoserine binding; phosphothreonine binding; proline-rich region binding; proline-rich region binding; protein binding; protein domain specific binding; sodium channel inhibitor activity; ubiquitin binding; ubiquitin-protein ligase activity;
Pathway	Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem;
MIM	602278

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