Human MDC1 adenoviral particles

Name: Human MDC1 adenoviral particles
SKU: AD09776Z
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : AD09776Z

Storage : -80℃ Shipping : Frozen on dry ice

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Virus Particles Information

Quality Control

Gene Information

Cat. No.	AD09776Z
Description	Adenovirus with ORF of mediator of DNA-damage checkpoint 1 (MDC1).
Gene	MDC1
Species	Human
Titer	Varies lot by lot, for example, ≥1x10^10 IFU/mL, ≥1x10^11 IFU/mL, ≥1x10^11 VP/mL etc.
Size	Varies lot by lot, for example, 100 ul, 500 ul, 1 mL etc.
Storage	Store at -80℃. Avoid multiple freeze/thaw cycles.
Shipping	Frozen on dry ice

Summary	Creative Biogene ensures high-quality adenovirus particles by optimizing and standardizing production protocols and performing stringent quality control (QC). The specific QC experiments performed vary between adenovirus particle lots.
Endotoxin	Endotoxins, primarily derived from Gram-negative bacteria, can trigger adverse immune responses. Endotoxin contamination is a significant concern in adenovirus production, especially for applications in animal studies and gene therapy. Creative Biogene utilizes rigorous endotoxin detection methods to monitor the endotoxin level in our produced adenovirus particles to ensure regulatory compliance.
Sterility	Creative Biogene ensures that adenovirus products are free of any bacterial, fungal and other microbial contamination.
Ad5 E1 Detection	All Creative Biogene adenoviruses are PCR tested to ensure that there are no detectable E1 sequences in the particles, which could be from revertants or external E1 contamination.
RCA Assays	Adenovirus products originating at Creative Biogene are guaranteed to have undetectable replication-competent adenovirus (RCA). This quality control measure is important because there is always the possibility of wild-type contamination due to revertants or environmental sources.
PFU Titering	All purified adenovirus preparations are tested for infectious titer. Creative Biogene's PFU test takes a few days longer but counts true plaques in HEK cells rather than estimating PFU titers via IHC staining or TCI50 of infected cells.

Gene Name	MDC1 mediator of DNA-damage checkpoint 1 [ Homo sapiens ]
Gene Symbol	MDC1
Synonyms	NFBD1
Gene Description	mediator of DNA damage checkpoint 1
GeneID	9656
Uni ProtID	A1Z5I9
mRNA Refseq	NM_014641.2
Protein Refseq	NP_055456.2
Chromosome Location	6p21.3
Function	FHA domain binding; protein C-terminus binding; protein binding;
Pathway	ATM mediated phosphorylation of repair proteins, organism-specific biosystem; ATM mediated response to DNA double-strand break, organism-specific biosystem; DNA Repair, organism-specific biosystem; Double-Strand Break Repair, organism-specific biosystem; Homologous Recombination Repair, organism-specific biosystem; Homologous recombination repair of replication-independent double-strand breaks, organism-specific biosystem; Recruitment of repair and signaling proteins to double-strand breaks, organism-specific biosystem;
MIM	607593

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