Human ITGA5 adenoviral particles

The ITGA5 gene encodes integrin alpha-5 (ITGA5), a key subunit of the heterodimeric transmembrane receptor integrin α5β1. The receptor plays a key role in cell adhesion, migration, and signaling by binding to extracellular matrix (ECM) proteins such as fibronectin, facilitating interactions between cells and their microenvironment. ITGA5 is involved in a variety of physiological processes, including embryonic development, angiogenesis, wound healing, and immune responses. Dysregulation of ITGA5 has been implicated in pathological conditions such as cancer metastasis, fibrosis, and inflammatory diseases, making it a target for therapeutic investigation.

Human ITGA5 adenoviral particles are recombinant viral vectors engineered to deliver the ITGA5 gene to target cells for overexpression studies. These particles utilize adenoviral technology, which allows for high transduction efficiencies in a variety of cell types, including dividing and non-dividing cells. The adenoviral backbone is modified to ensure safety, typically by deleting essential viral replication genes (E1/E3 regions). Following infection, ITGA5 genes are expressed in host cells, allowing researchers to study their functional roles in adhesion, migration, and downstream signaling pathways. In addition, they can serve as tools for gene therapy development, particularly for diseases where cell-extracellular matrix (ECM) interactions are disrupted.