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Human GFP-NFkBp65/Hyg Reporter Stable Cell Line-CHO

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Cat.No.
CSC-RR0038
Background
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO
Stability
Cells will undergo genotypic changes resulting in reduced responsiveness over time in normal cell culture conditions. Genetic instability is a biological phenomenon that occurs in all stably transfected cells. Therefore, it is critical to prepare an adequate number of frozen stocks at early passages.
Ship
Dry ice
Gene Information
Official Symbol
RELA
Synonyms
RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian); NFKB3, nuclear factor of kappa light polypeptide gene enhancer in B cells 3; transcription factor p65; p65; NF-kappa-B p65delta3; nuclear factor NF-kappa-B p65 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NFKB3; MGC131774;
Gene ID
MIM
UniProt ID
Q04206
Chromosome Location
11q13
Pathway
Activated TLR4 signalling, organism-specific biosystem; Activation of NF-kB in B Cells, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem;
Function
DNA binding; NF-kB binding; activating transcription factor binding; ankyrin repeat binding; chromatin binding; identical protein binding; identical protein binding; phosphate ion binding; protein N-terminus binding; protein binding; protein kinase binding; repressing transcription factor binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; transcription factor binding; transcription regulatory region DNA binding; ubiquitin protein ligase binding;

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