Transfected Stable Cell Lines
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Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : AD00158Z
Storage : -80℃ Shipping : Frozen on dry ice
Titer: Size:
| Cat. No. | AD00158Z |
| Product Type | Adenoviral particle |
| Gene | DYRK4 |
| Titer | Varies lot by lot, for example, ≥1x10^10 IFU/mL, ≥1x10^11 IFU/mL, ≥1x10^11 VP/mL etc. |
| Size | Varies lot by lot, for example, 100 ul, 500 ul, 1 mL etc. |
| Storage | Store at -80℃. Avoid multiple freeze/thaw cycles. |
| Shipping | Frozen on dry ice |
| Summary | Creative Biogene ensures high-quality adenovirus particles by optimizing and standardizing production protocols and performing stringent quality control (QC). The specific QC experiments performed vary between adenovirus particle lots. |
| Endotoxin | Endotoxins, primarily derived from Gram-negative bacteria, can trigger adverse immune responses. Endotoxin contamination is a significant concern in adenovirus production, especially for applications in animal studies and gene therapy. Creative Biogene utilizes rigorous endotoxin detection methods to monitor the endotoxin level in our produced adenovirus particles to ensure regulatory compliance. |
| Sterility | Creative Biogene ensures that adenovirus products are free of any bacterial, fungal and other microbial contamination. |
| Ad5 E1 Detection | All Creative Biogene adenoviruses are PCR tested to ensure that there are no detectable E1 sequences in the particles, which could be from revertants or external E1 contamination. |
| RCA Assays | Adenovirus products originating at Creative Biogene are guaranteed to have undetectable replication-competent adenovirus (RCA). This quality control measure is important because there is always the possibility of wild-type contamination due to revertants or environmental sources. |
| PFU Titering | All purified adenovirus preparations are tested for infectious titer. Creative Biogene's PFU test takes a few days longer but counts true plaques in HEK cells rather than estimating PFU titers via IHC staining or TCI50 of infected cells. |
| Gene Name | DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [ Homo sapiens ] |
| Gene Symbol | DYRK4 |
| Synonyms | DYRK4; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4; dual specificity tyrosine-phosphorylation-regulated kinase 4; |
| Gene ID | 8798 |
| Uni Prot ID | Q9NR20 |
| m RNA Refseq | BC031244 |
| Chromosome Location | 12p13.32 |
| Function | ATP binding; metal ion binding; nucleotide binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; |
| MIM | 609181 |
The Dual Specificity Tyrosine Phosphorylation Regulated Kinase 4 (DYRK4) gene encodes a member of the DYRK protein kinase family, which plays a critical role in processes such as cell proliferation, differentiation, and apoptosis. DYRK4 is characterized by its ability to phosphorylate both serine/threonine and tyrosine residues, which makes it a versatile regulator in signaling pathways. This kinase has been implicated in a variety of physiological and pathological states, including neurodevelopment, cancer progression, and metabolic regulation. Studies have shown that DYRK4 may affect cell cycle regulation and stress responses, making it a potential target for therapeutic intervention.
Human DYRK4 Adenoviral Particles are genetically engineered viral vectors designed to deliver the DYRK4 gene to target cells for functional studies or therapeutic purposes. These particles are derived from a replication-defective adenovirus, which ensures efficient transduction while minimizing the risks associated with viral replication. This adenoviral system has high transduction efficiencies in a variety of cell types, including dividing and non-dividing cells, making it a valuable tool for gene overexpression experiments. Human DYRK4 adenoviral particles enable researchers to study the role of DYRK4 in cellular pathways, disease models, or drug screening assays. In addition, these particles can be used in gene therapy studies to modulate the expression of DYRK4 in specific tissues.
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