DYRK4 adenovirus

Dual-specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4), a member of the DYRK protein kinase family, plays a critical role in processes such as cell proliferation, differentiation, and survival. DYRK4 is characterized by its ability to simultaneously phosphorylate tyrosine and serine/threonine residues, thereby participating in the regulation of various signaling pathways. Although less well-studied than other DYRK family members such as DYRK1A or DYRK2, emerging research suggests that DYRK4 is involved in developmental processes, cell cycle regulation, and potentially in disease mechanisms such as cancer and neurological disorders. Its expression in multiple tissues suggests its broad functional significance. Further research on DYRK4 holds promise for identifying new therapeutic targets, particularly in diseases associated with kinase dysregulation.

The DYRK4 adenovirus is a recombinant viral vector designed to deliver and express the DYRK4 gene in target cells. It is a powerful tool for studying gene function and potential therapeutic applications. Adenoviral vectors are widely used in molecular biology due to their high transduction efficiency, ability to infect both dividing and non-dividing cells, and ability to carry large gene inserts. The DYRK4 adenovirus enables researchers to overexpress the DYRK4 kinase in vitro or in vivo, facilitating the study of its biological roles, downstream signaling pathways, and interactions with other cellular proteins. Furthermore, this vector can be used for gene therapy research, particularly in diseases where DYRK4 regulation may provide therapeutic benefit.