Human COPS5 adenoviral particles

The COPS5 gene (also known as CSN5 or JAB1) encodes the fifth subunit of the COP9 signalosome (CSN), a highly conserved protein complex involved in critical cellular processes such as protein degradation, signal transduction, and cell cycle regulation. COPS5 plays a key role in the regulation of the ubiquitin-proteasome system by controlling the activity of cullin-RING ubiquitin ligases (CRLs), which are essential for targeting proteins for degradation. In addition, COPS5 is involved in the regulation of key signaling pathways, including the NF-κB and p53 pathways, affecting cell proliferation, apoptosis, and DNA damage response. Dysregulation of COPS5 is associated with a variety of diseases, including cancer, inflammation, and neurodegenerative diseases, making it an important target for biomedical research.

Human COPS5 Adenoviral Particles are genetically engineered viral vectors designed to deliver the COPS5 gene to mammalian cells for functional studies or therapeutic purposes. These particles are based on adenovirus, a highly efficient gene delivery system known for its high transduction efficiency and ability to infect both dividing and non-dividing cells broadly. The adenoviral vector contains full-length human COPS5, ensuring stable expression of the COPS5 protein in target cells. These particles are particularly important for gain-of-function experiments, allowing researchers to investigate the role of COPS5 in cellular processes such as ubiquitination, cell cycle progression, and stress responses. In addition, they are a powerful tool for gene therapy studies, particularly for diseases associated with dysregulation of COPS5.