Human CLDN3 adenoviral particles

The CLDN3 gene encodes claudin-3 (CLDN3), which belongs to the tight junction protein family and plays a key role in maintaining cell polarity, barrier function, and intercellular communication. Claudin is an integral membrane protein that forms the backbone of tight junctions and selectively regulates paracellular permeability and ion transport across the epithelium and endothelium. CLDN3 is particularly abundant in tissues such as the kidney, liver, and gastrointestinal tract, where it helps maintain tissue integrity and fluid homeostasis. Dysregulation of CLDN3 has been implicated in a variety of pathological conditions, including cancer, and its overexpression or inhibition can affect tumor progression, metastasis, and drug resistance. Due to its involvement in cell adhesion and signaling pathways, CLDN3 has emerged as a potential therapeutic target and biomarker for diseases characterized by epithelial barrier dysfunction.

Human CLDN3 adenoviral particles are engineered viral vectors designed to deliver the CLDN3 gene to target cells for research or therapeutic purposes. These particles are based on an adenovirus serotype (usually Ad5) that has been modified to be replication-defective, ensuring safety while maintaining high transduction efficiency in a variety of cell types, both dividing and non-dividing. These particles are widely used in functional studies to investigate the role of CLDN3 in tight junction formation, epithelial barrier regulation, and disease mechanisms. In addition, they can serve as a tool for gene therapy studies, especially in diseases where CLDN3 modulation may restore normal cellular function.