BCL10 Validated sgRNA vector

Name: BCL10 Validated sgRNA vector
SKU: SKO0331
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : SKO0331

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Product Information

Vector Map

Gene Information

Cat. No.	SKO0331
Description	Creative Biogene develops and optimizes genome editing technology to produce stable genome edited mammalian cell lines serving a wide-range of R&D activities in areas of basic research, diagnostic and therapeutic development. Our premade SuperKO sgRNA vectors are tailor-made to target many different genes respectively. We have successfully constructed a series of knockout cell lines using those sgRNAs.
Gene Abbr	BCL10
Reporter	mCherry
Promoter	U6
Resistance	Amp
Selection	Ampicillin
Vector Type	Lentiviral Expression
Vector Length	7677 bp

Target Gene

BCL10

Background

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

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