shRNA set against Mouse NPM1 (NM_008722.3)

Name: shRNA set against Mouse NPM1 (NM_008722.3)
SKU: SHH354316
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : SHH354316

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Product Information

Gene Information

Cat. No.	SHH354316
Description	The SureSilencing trade; shRNA Plasmids are designed to specifically knock down the expression of individual genes by RNA interference under either transient (with GFP) or stable transfection (for hygromycin, neomycin or puromycin-resistance) conditions after performance of the appropriate enrichment or selection procedures, respectively. Each vector contains the shRNA under control of the U1 promoter and either the GFP gene, for the enrichment of transiently transfected cells, or the neomycin or puromycin resistance genes, for the selection of stably transfected cells.
Gene Abbr	NPM1
Species	Mouse
Report Gene	GFP
Storage	The SureSilencing shRNA Plasmids are shipped on dry ice or cold packs. Store all tubes at -20°C.

Target Gene

NPM1

Background

The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]

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