SEPP1 Selenium Transport Function Genotyping Kit

The SEPP1 gene encodes selenoprotein P, the major selenium transport protein synthesized and secreted by the liver into plasma, responsible for transporting selenium from the liver to peripheral tissues such as the prostate, retina, breast, and brain, playing a core role in maintaining selenium homeostasis and antioxidant defense. The key functional polymorphism locus in the 3'-UTR region of this gene shows that carriers of the variant allele have significantly lower serum and tissue selenium levels than wild-type homozygotes, in a dose-dependent manner. This effect modulates susceptibility to various diseases—including prostate cancer incidence and recurrence risk, retinopathy of prematurity, breast cancer tissue selenium concentration, and sleep disorders—by reducing selenoenzyme antioxidant activity and increasing oxidative stress damage, while also affecting individual metabolic responses to selenium supplementation. The research significance of this locus lies in providing a detectable genetic biomarker for disease risk prediction and a genetic guidance basis for individualized selenium nutritional intervention, with broad prospects for translation into clinical detection products in fields such as high-risk prostate cancer population screening, premature infant ROP risk warning, and precision nutritional supplementation.