BDNF Alzheimer's Disease Risk Genotyping Kit

Name: BDNF Alzheimer's Disease Risk Genotyping Kit
SKU: GK-0008
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : GK-0008

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Product Information

Cat. No.	GK-0008
Description	Leveraging two major technology platforms—KASP (Kompetitive Allele-Specific PCR) and TaqMan MGB probes—we provide cost-effective or ultra-high-specificity custom genotyping services for any species and any genetic locus.
Introduction	If the customer provides a specific genotyping RS number, we can perform custom development and offer SNP testing services upon receipt of mailed blood/tissue/cell samples. The customer needs to provide: 1. Sample materials such as cells (≥10^6 cells), tissue (≥300 mg), blood (≥1 ml), serum (≥1.5 ml), etc.; nucleic acid extraction is charged separately; 2. Genomic DNA (volume ≥30 μl, concentration ≥50 ng/μl), with purity OD260/280 between 1.7 and 1.9; 3. For the human genome, the RS number of the SNP locus must be provided. For other species without rs numbers, such as cattle, chickens, and fish, the exact 200 bp sequences flanking both upstream and downstream of the SNP locus must be provided, along with the mutation type at the SNP locus and whether any other linked loci exist within 25 bp upstream or downstream of the locus. We deliver: 1. SNP results (Excel spreadsheet); 2. Complete experimental report: amplification and reaction systems, primers involved, and probe sequences; Scatter plot of clustering results (KASP method) / Amplification curves and Ct value analysis (TaqMan MGB method). 3. Other relevant materials required by the customer.
Gene	BDNF
Features	Genotyping Accuracy >99%
Applications	Research Use
Size	Box
Format	100T
Note	All SNP kits are custom-developed and not available from stock. Primers and probes are individually designed and synthesized based on the RS numbers or target sequences provided by the customer.
Storage	-20℃

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A single nucleotide polymorphism in a key functional region of the BDNF gene serves as an important genetic marker for the regulation of neurotrophic factor secretion and has clear clinical value in the risk stratification of Alzheimer's disease. This locus regulates hippocampal synaptic plasticity, neuronal survival, and cognitive function maintenance by affecting the intracellular trafficking efficiency and active secretion level of the BDNF protein. Multiple large-scale international meta-analyses have confirmed that carriers of the variant allele show a significantly increased risk of Alzheimer's disease among women, particularly among postmenopausal women and late-onset patients, suggesting a specific interaction between this locus and the estrogen signaling pathway. Genotyping detection kits based on technologies such as TaqMan probes or high-throughput sequencing enable rapid and accurate identification of this locus, providing a reliable molecular basis for individualized risk assessment, early intervention strategy development, and dynamic monitoring of cognitive decline. In the future, with the refinement of polygenic risk scoring systems and the advancement of precision medicine, this locus is expected to be applied in combination with classic risk markers such as APOE-ε4 to build a more comprehensive Alzheimer's disease genetic risk assessment framework, promoting a shift in the diagnosis and treatment paradigm from "passive treatment" to "active prevention" and providing scientific guidance for the health management of high-risk populations.

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