SELENOS Inflammation Susceptibility Genotyping Kit

Selenoprotein S (Selenoprotein S, SELENOS/SEPS1) is an important selenium-dependent protein mainly localized to the endoplasmic reticulum membrane, participating in key biological processes such as endoplasmic reticulum stress regulation, misfolded protein degradation, inflammatory response regulation, and antioxidant protection. The -105G/A locus upstream of the SELENOS gene promoter region is the most extensively studied important functional single nucleotide polymorphism (SNP) of this gene, with G/A and G/C alleles, where G is the wild-type allele and A and C are mutant alleles. Studies have found that this SNP locus regulates SELENOS gene transcriptional activity by affecting the integrity of transcription factor binding sites; G allele carriers have higher SELENOS expression levels, stronger ER stress regulatory capacity, and lower inflammatory responses, whereas A allele carriers show reduced SELENOS expression and increased pro-inflammatory cytokine production, forming a chronic inflammatory state. The AA/GA genotypes are significantly associated with susceptibility to various diseases, including infectious diseases (brucellosis, EV71 virus infection), malignant tumors (gastric cancer), cardiovascular diseases (coronary heart disease, ischemic stroke), and metabolic diseases (type 2 diabetes, gestational diabetes), with A allele carriers showing a 1.3- to 1.8-fold increased disease risk. Allele frequencies vary by ethnicity; among the Chinese Han population, the G allele frequency is approximately 0.60-0.65 and the A allele frequency approximately 0.35-0.40. In addition, this locus exhibits interaction effects with environmental factors such as selenium nutritional status and metal exposure, and AA genotype individuals may benefit more from selenium supplementation interventions. Research on this promoter locus provides an important molecular marker for disease risk prediction, individualized nutritional intervention, and precision medicine, with broad clinical application prospects, but larger-scale multicenter studies are still needed to validate its association strength and specific molecular mechanisms across different populations.