Recombinant Cynomolgus PVRL4 (C-6His)

Name: Recombinant Cynomolgus PVRL4 (C-6His)
SKU: RP00413
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00413 Tag : C-6His

Expressed Region : Gly32-Ser349 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00413
Description	Recombinant Cynomolgus PVRL4 (C-6His) is produced in our Human Cell expression system. The amino acid region expressed is Gly32-Ser349 with a 6His tag at the C terminus.
Species	Cynomolgus
Tag	C-6His
Mol Weight	34.9 KDa
Conjugate	Unconjugated
Format	Powder
Expressed Region	Gly32-Ser349
Expression System	Human Cell
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	PVRL4
Synonyms	PVRL4; Nectin-4; Ig superfamily receptor LNIR; Poliovirus receptor-related protein 4; PRR4; LNIR

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This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

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