Mouse Phb2 Stable Cell Line - RAW 264.7

The Phb2 gene encodes the prohibitin-2 protein, which is located on the inner mitochondrial membrane and forms a cyclic complex with PHB1. PHB2 acts as a molecular chaperone, crucial for mitochondrial morphology and respiratory chain assembly. In addition to its role in mitochondria, PHB2 is a selective mitophagy receptor, connecting LC3 to the inner mitochondrial membrane. Furthermore, PHB2 can translocate to the nucleus, acting as a co-repressor of estrogen receptor-mediated transcription. Clinically, PHB2 dysfunction is associated with metabolic syndrome, neurodegenerative diseases, and cancer, in which PHB2 maintains mitochondrial function and protects cells from stress.

A stable mouse Phb2 cell line in the RAW 264.7 context is a dedicated model for studying mitochondrial quality control in macrophage function. RAW 264.7 cells are used to study phagocytosis and responses to pathogens, processes highly dependent on mitochondrial energy production. This cell line provides a stable platform for mouse Phb2 expression, enabling researchers to analyze how prohibitin levels affect mitophagy flux and inflammatory responses. This product is ideal for screening compounds that can modulate PHB2 activity to enhance mitochondrial health in chronic inflammatory diseases or disrupt the stability of drug-resistant cancer cells.