Human MRC2 Stable Cell Line - HEK293

MRC2, also known as mannose receptor C-type 2, CD280, UPARAP, or ENDO180, is a member of the mannose receptor family encoded by the MRC2 gene located on chromosome 17q23.2. The protein is a transmembrane receptor that contains a fibronectin type II domain and multiple C-type lectin-like domains, and it plays a critical role in extracellular matrix remodeling by binding, internalizing, and delivering collagen ligands to lysosomes for degradation. MRC2 is ubiquitously expressed in human tissues, with higher levels observed in the gallbladder, ovary, and other organs. The Human MRC2 Stable Cell Line - HEK293 is generated by stably transfecting the human MRC2 gene into HEK293 cells, a well-established human embryonic kidney cell line widely used in biomedical research due to its high transfection efficiency and reliable protein expression. This stable cell line provides a consistent and reproducible in vitro system for studying MRC2 function, regulation, and interaction with binding partners, offering advantages over transient expression systems by ensuring sustained and uniform MRC2 expression across passages.

The Human MRC2 Stable Cell Line - HEK293 is a valuable tool for a wide range of research applications. It can be used to investigate the molecular mechanisms underlying MRC2-mediated collagen uptake and degradation, which are essential processes in tissue remodeling, fibrosis, and cancer progression. Researchers studying tumor biology can employ this cell line to explore the role of MRC2 in the invasion and metastasis of malignancies such as breast cancer, gliomas, and osteolytic bone disease. The stable cell line is also suitable for screening compounds that modulate MRC2 activity, supporting drug discovery efforts targeting collagen catabolism and extracellular matrix turnover. Additionally, it serves as a reliable control or overexpression system for functional studies of downstream signaling pathways, receptor-mediated endocytosis, and protein-protein interactions.