Human LINC01116 Stable Cell Line - U-87 MG

Long intergenic non-protein coding RNA 1116 (LINC01116), commonly abbreviated as LINC01116, is localized to band 2q31.1 on human chromosome 2. Although it does not translate into a protein, it plays an indispensable regulatory role in numerous fundamental cellular physiological processes. Mounting scientific evidence has conclusively established that LINC01116 acts as a potent oncogene in a variety of human malignancies—most notably in glioblastoma, breast cancer, lung cancer, and colorectal cancer. Within the cellular microenvironment, LINC01116 exerts its profound biological effects through a diverse array of epigenetic and post-transcriptional regulatory mechanisms. It most frequently functions as a "competing endogenous RNA" (ceRNA), essentially acting as a "molecular sponge" by sequestering specific tumor-suppressor microRNAs (miRNAs). This action, in turn, leads to the upregulation of downstream target genes, thereby driving tumor initiation and progression. Furthermore, studies indicate that LINC01116 can interact with chromatin-modifying complexes, thereby altering the cellular transcriptional landscape and creating conditions conducive to malignant transformation.

The human LINC01116 stable cell line, established within a U-87 MG cellular background, represents a meticulously designed and highly specialized in vitro research tool; it is engineered to accelerate research progress regarding this long non-coding RNA within the field of neuro-oncology. U-87 MG is a human primary glioblastoma cell line, highly favored by the scientific community for its robust growth characteristics and its ability to accurately recapitulate the features of brain tumors of astrocytic origin. This customized stable cell line was constructed using advanced gene integration technologies, ensuring the continuous, stable, and reliable expression of the LINC01116 gene—or enabling the precise regulation of its expression levels. Researchers can readily utilize this product to conduct comprehensive in vitro functional assays, such as real-time monitoring of cell proliferation, assessment of apoptosis, and rigorous studies of cell migration and invasion. Furthermore, this cell line provides an ideal physiological platform for exploring the complex intracellular signaling pathways directly regulated by LINC01116.