Human CLDN5 Nanodisc

Name: Human CLDN5 Nanodisc
SKU: OE-PNDC000848
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : OE-PNDC000848

Tag : C-Flag tag and Strep Tag Expression System : Mammalian expression system

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Product Information

Gene Information

Cat. No.	OE-PNDC000848
Description	Human CLDN5 nanodisc contains full length human CLDN5 protein that is produced from HEK293 cells. Our nanodisc platform employs the mammalian expression system, which ensures that the Human CLDN5 protein closely resembles its native counterpart in terms of structure, function, and post-translational modifications, while maintaining exceptional solubility and stability. This nanodisc is an optimal tool for investigating the Human CLDN5 membrane protein.
Gene Abbr	CLDN5
Gene Name	CLDN5
Species	Human
Gene Species	Human
Tag	C-Flag tag and Strep Tag
Features	1) Full-length membrane protein 2) Utilizing a mammalian expression system to ensure that the protein closely resembles its native counterpart in terms of structure, function, and post-translational modifications 3) Maintaining the native spatial conformation and activity of the membrane protein 4) Possessing high solubility and stability 5) High purity determined by HPLC 6) No detergents need to be added in subsequent experiments, and it can be directly applied to cytological analysis
Applications	1) Studying protein structure and function: Understanding the structure and activity of membrane proteins in a native-like environment. 2) Studying protein-protein and protein-ligand interactions: Analyzing how membrane proteins interact with other molecules, such as antibodies or other proteins. 3) Drug discovery: Identifying and characterizing potential drug candidates that target membrane proteins. 4) Developing antibodies: Screening and characterizing antibodies that bind to membrane proteins.
Format	Lyophilized protein
Expression System	Mammalian expression system
Note	For Research Use Only.
Storage	Store at -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within one month, aliquot and store at -80°C. Repeated freeze-thaw cycles should be avoided.
Shipping	Lyophilized proteins are shipped under ambient temperature conditions.

Target Gene

CLDN5

Background

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]

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