PGRN Alzheimer's Disease Risk Genotyping Kit

Name: PGRN Alzheimer's Disease Risk Genotyping Kit
SKU: GK-0009
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : GK-0009

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Product Information

Cat. No.	GK-0009
Description	Leveraging two major technology platforms—KASP (Kompetitive Allele-Specific PCR) and TaqMan MGB probes—we provide cost-effective or ultra-high-specificity custom genotyping services for any species and any genetic locus.
Introduction	If the customer provides a specific genotyping RS number, we can perform custom development and offer SNP testing services upon receipt of mailed blood/tissue/cell samples. The customer needs to provide: 1. Sample materials such as cells (≥10^6 cells), tissue (≥300 mg), blood (≥1 ml), serum (≥1.5 ml), etc.; nucleic acid extraction is charged separately; 2. Genomic DNA (volume ≥30 μl, concentration ≥50 ng/μl), with purity OD260/280 between 1.7 and 1.9; 3. For the human genome, the RS number of the SNP locus must be provided. For other species without rs numbers, such as cattle, chickens, and fish, the exact 200 bp sequences flanking both upstream and downstream of the SNP locus must be provided, along with the mutation type at the SNP locus and whether any other linked loci exist within 25 bp upstream or downstream of the locus. We deliver: 1. SNP results (Excel spreadsheet); 2. Complete experimental report: amplification and reaction systems, primers involved, and probe sequences; Scatter plot of clustering results (KASP method) / Amplification curves and Ct value analysis (TaqMan MGB method). 3. Other relevant materials required by the customer.
Gene	PGRN
Features	Genotyping Accuracy >99%
Applications	Research Use
Size	Box
Format	100T
Note	All SNP kits are custom-developed and not available from stock. Primers and probes are individually designed and synthesized based on the RS numbers or target sequences provided by the customer.
Storage	-20℃

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Specific functional variants of the PGRN gene (Progranulin) significantly affect the genetic susceptibility and disease progression of Alzheimer's disease by regulating the level of its encoded protein. This locus participates in neuronal survival and pathological protein homeostasis regulation by influencing the neuroprotective function of PGRN; its risk allele exhibits a synergistic pathogenic effect with APOE ε4—in APOE ε4 carriers, this variant can significantly exacerbate β-amyloid toxicity and neuroinflammation, increasing disease risk by multiples, making it a key genetic marker for the precise identification of high-risk populations. Developing an SNP genotyping detection kit targeting this locus will facilitate individualized risk assessment and early warning based on genetic background, provide a precise intervention window for susceptible individuals carrying APOE ε4, and promote a shift in Alzheimer's disease prevention and control from traditional symptomatic treatment to early genetic stratification management. In the future, integrating multi-omics to elucidate the synergistic pathogenic mechanism of this variant with APOE ε4 is expected to provide innovative targets for intervention strategies targeting neuroprotection and pathological protein regulation, accelerating the translational application of precision medicine in the field of neurodegenerative diseases.

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