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Monkey FOLH1 Stable Cell Line - HEK293T

Monkey FOLH1 Stable Cell Line - HEK293T

Cat.No. :  CSC-RO0561 Host Cell:  HEK293T

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Cell Line Information

Cell Culture Information

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Cat. No. CSC-RO0561
Description This cell line is derived from HEK293T and is engineered to stably overexpress Cyno FOLH1.
Gene FOLH1
Host Cell HEK293T
Stability Validated for at least 10 passages
Application

1. Gene expression studies

2. Signaling pathway research

3. Drug screening and toxicology

4. Disease research

Quality Control Negative for bacteria, yeast, fungi and mycoplasma.
Shipping Dry ice
Storage Liquid nitrogen
Revival Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties Cells are cultured as a monolayer at 37°C in a humidified atmosphere with 5% CO2. Split at 80-90% confluence, approximately 1:3-1:6.
Mycoplasma Negative
Format One frozen vial containing millions of cells
Storage Liquid nitrogen
Safety Considerations

The following safety precautions should be observed.

1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum.

2. No eating, drinking or smoking while handling the stable line.

3. Wash hands after handling the stable line and before leaving the lab.

4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells.

5. All waste should be considered hazardous.

6. Dispose of all liquid waste after each experiment and treat with bleach.

Ship Dry ice
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Background

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The FOLH1 gene, also known as folylpolyglutamate synthetase, is a protein-coding gene in monkeys. The protein encoded by this gene has two main functions. It plays an important role in folate metabolism and is involved in the synthesis of foylpolyglutamic acid, a compound necessary for the synthesis of purines and pyrimidines. FOLH1 protein is expressed in multiple tissues, including kidney, liver, intestine, and placenta, demonstrating its widespread importance in metabolic processes. Mutations in the FOLH1 gene are associated with a variety of cancers. The protein encoded by this gene is also a highly specific biomarker for prostate cancer and is used in prognosis and imaging of the disease. Furthermore, it has recently been used as a target for immunotherapeutic strategies for prostate cancer treatment. The monkey FOLH1 stable cell line is a specially designed cell line expressing the monkey-derived FOLH1 gene. This cell line is critical for a variety of biomedical and genetic research efforts, primarily due to its stable expression of the FOLH1 gene. The Monkey FOLH1 stable cell line is a reliable and consistent tool for conducting a wide range of laboratory studies related to these conditions. It enables researchers to study the mechanisms of these diseases at the cellular level, making a significant contribution to the development of potential treatments and treatment strategies.
The Monkey FOLH1 Stable Cell Line has multiple applications, particularly within the field of biological research and drug development. Protein Expression Studies: These stable cell lines can be used as in vitro models to understand the gene expression and mechanisms of the FOLH1 gene. Scientists can investigate how this gene contributes to physiological and pathological processes in monkeys. Drug Screening: The Monkey FOLH1 Stable Cell Line can be used for high-throughput screenings of potential drugs. By observing how these drugs affect the function and survival of these cells, scientists can identify promising therapeutic candidates. Toxicity Testing: The cell line can also be used in toxicity studies. Researchers can expose these cells to various substances to see how they react, providing valuable information about the potential toxicity of new drugs or other materials. Disease Modeling: Since FOLH1 gene is implicated in several diseases such as cancer, these cells can be used to model these conditions. This is helpful in understanding the disease pathogenesis and identifying potential targets for therapeutic intervention. Genetic Studies: These cell lines can also facilitate studies exploring the impact of genetic variations on the function of the FOLH1 gene.
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Customer Reviews
Ease of use

This Monkey FOLH1 Stable Cell Line stood out for its robustness and ease of use. It was clear that a lot of effort was put into its development, and it has greatly streamlined our workflow.

United States

09/15/2023

High quality

As a repeat customer, I am impressed by the high quality and stability of Creative Biogene's stable cell line. It has become a cornerstone of our cell research, providing reproducible results every time.

United States

09/10/2022

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