CD33 Alzheimer's Disease Risk Genotyping Kit

Name: CD33 Alzheimer's Disease Risk Genotyping Kit
SKU: GK-0010
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : GK-0010

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Product Information

Cat. No.	GK-0010
Description	Leveraging two major technology platforms—KASP (Kompetitive Allele-Specific PCR) and TaqMan MGB probes—we provide cost-effective or ultra-high-specificity custom genotyping services for any species and any genetic locus.
Introduction	If the customer provides a specific genotyping RS number, we can perform custom development and offer SNP testing services upon receipt of mailed blood/tissue/cell samples. The customer needs to provide: 1. Sample materials such as cells (≥10^6 cells), tissue (≥300 mg), blood (≥1 ml), serum (≥1.5 ml), etc.; nucleic acid extraction is charged separately; 2. Genomic DNA (volume ≥30 μl, concentration ≥50 ng/μl), with purity OD260/280 between 1.7 and 1.9; 3. For the human genome, the RS number of the SNP locus must be provided. For other species without rs numbers, such as cattle, chickens, and fish, the exact 200 bp sequences flanking both upstream and downstream of the SNP locus must be provided, along with the mutation type at the SNP locus and whether any other linked loci exist within 25 bp upstream or downstream of the locus. We deliver: 1. SNP results (Excel spreadsheet); 2. Complete experimental report: amplification and reaction systems, primers involved, and probe sequences; Scatter plot of clustering results (KASP method) / Amplification curves and Ct value analysis (TaqMan MGB method). 3. Other relevant materials required by the customer.
Gene	CD33
Features	Genotyping Accuracy >99%
Applications	Research Use
Size	Box
Format	100T
Note	All SNP kits are custom-developed and not available from stock. Primers and probes are individually designed and synthesized based on the RS numbers or target sequences provided by the customer.
Storage	-20℃

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The CD33 gene is an important immune regulatory target in the study of Alzheimer's disease (AD) genetic susceptibility. The sialic acid-binding immunoglobulin-like lectin-3 it encodes is expressed on the microglial cell surface and negatively regulates Aβ clearance capacity. The two well-characterized functional polymorphism loci in the intronic and promoter regions of the CD33 gene detected by this kit both have the reference allele C, whereas the variant alleles enhance microglial phagocytic clearance of β-amyloid by promoting exon 2 splice skipping to generate the CD33m short isoform and by reducing promoter activity to decrease total CD33 expression, respectively. These variant alleles have been confirmed as protective alleles in multiple large-scale GWAS studies. This kit adopts a dual-locus combined detection strategy that simultaneously evaluates genetic risk at both the splicing-regulatory and expression-regulatory levels, providing a molecular basis for early AD risk stratification, high-risk population screening, and personalized intervention.

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