AvFc Stable Cell Line - CHO-K1

Avaren-Fc (AvFc) is a unique and innovative fusion protein composed of a variant of the actinomycete lectin actinomycin (Avaren) and the Fc (crystallizable fragment) region of human immunoglobulin G1 (IgG1). Avaren is a natural sugar-binding protein produced by actinomycetes. This lectin is noteworthy because of its high specificity for binding to high-mannose-type sugar chains, which are often found on the surfaces of various types of viruses and glycosylated proteins. Due to this property, Avaren is considered for its great potential as an effective antiviral agent in the field of virology against particularly dangerous and widespread viruses (such as HIV). However, in order for Avaren to be used effectively in vivo, modifications were required, resulting in Avaren-Fc. The Fc region of an antibody (such as human IgG1) is responsible for triggering the immune response. By merging this part of the antibody with Avaren, two significant benefits are achieved. First, the fusion molecule inherits the long metabolic half-life of the Fc fragment, thereby enhancing the duration of Avaren's therapeutic effects in the body. Second, because the human Fc region is readily recognized by the body, it enhances the potential of Avaren-Fc to trigger a more robust immune response against affected cells displaying high mannose chains.