aFGF adenovirus

The acidic fibroblast growth factor (aFGF) adenovirus is a recombinant viral vector designed to deliver the aFGF gene to target cells for therapeutic or research purposes. Adenovirus is a nonenveloped, double-stranded DNA virus widely used in gene therapy due to its high transduction efficiency, broad tissue tropism, and ability to infect both dividing and non-dividing cells. The aFGF gene encodes a potent mitogenic protein that plays a key role in cell proliferation, angiogenesis, and tissue repair. By integrating the aFGF gene into the adenoviral backbone, this construct enables efficient transient expression of aFGF in vitro and in vivo. The adenoviral delivery system is particularly advantageous for short-term gene expression because it does not integrate into the host genome, minimizing the risk of insertional mutagenesis.

The aFGF adenovirus has broad applications in regenerative medicine, cardiovascular research, and wound healing. In regenerative medicine, it promotes tissue repair by stimulating the proliferation of fibroblasts, endothelial cells, and keratinocytes, making it valuable in the treatment of chronic wounds, burns, and diabetic ulcers. In cardiovascular research, aFGF adenovirus can be used to induce angiogenesis in ischemic tissues, providing a potential therapeutic strategy for coronary artery disease and peripheral arterial disease. Preclinical studies have shown that aFGF adenovirus can promote angiogenesis and improve tissue perfusion in animal models. Furthermore, aFGF adenovirus can be used as a tool in developmental biology to study the mechanisms of cell growth and differentiation.