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Cat.No. : CSC-RT0219
Host Cell: 293T Target Gene: VAMP8
Size: 1x10^6 cells/vial, 1mL Validation: Sequencing
| Cat. No. | CSC-RT0219 |
| Description | 293T-VAMP8 (-/-) is a stable cell line with a homozygous knockout of human VAMP8 |
| Background | This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010] |
| Target Gene | VAMP8 |
| Host Cell | 293T |
| Host Cell Species | Homo sapiens (Human) |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The knockout cell product is validated by PCR amplification and Sanger Sequencing to confirm the mutation at the genomic level. Please find the detailed mutation info in the datasheet.
A: Single clonal cell.
A: No. This knockout cell product is generated using the CRISPR/Cas9 system to induce small insertions or deletions (indels) resulting in frameshift mutations. Although these frameshift mutations typically disrupt the coding gene, there is a possibility that the non-functional transcript may still be transcribed. Consequently, this could potentially yield misleading results when analyzed by RT-qPCR.
A: The cell line should be stored in liquid nitrogen for long-term preservation.
A: For most cases, we often keep at least 2 clones with different frameshift mutations. Please feel free to contact us to check if there are additional available clones.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
VAMP8 Knockout Cell Line-293T has not only enriched my individual research endeavors but has also fostered a sense of collaboration and innovation within my research team.
United Kingdom
02/23/2023
VAMP8 Knockout Cell Line-293T's consistent performance has allowed me to build a strong foundation for future studies, empowering me to tackle more complex and ambitious research questions.
United States
04/11/2023
I have had the pleasure of presenting my findings at conferences, where VAMP8 Knockout Cell Line-293T's reliability and efficacy have garnered attention and praise from fellow researchers in the field.
United States
08/23/2020
Beyond the laboratory, VAMP8 Knockout Cell Line-293T has inspired me to engage in outreach activities, sharing the excitement of genetic research with students and sparking their interest in scientific exploration.
United States
05/12/2021
Looking ahead, I am eager to continue pushing the boundaries of knowledge with the support of this exceptional gene knockout reagent, confident in the discoveries yet to be made.
United States
08/15/2021
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