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Rat Zcchc8 cDNA Clone(NM_001105929.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR005657

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Gene Information

Cat. No. CDFR005657
Description NativeORF clone of Rattus norvegicus zinc finger, CCHC domain containing 8 (Zcchc8) as transfection-ready DNA NM_001105929.1
Product Type cDAN Clone
Gene Abbr Zcchc8
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene ZCCHC8
Background This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017]
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