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Rat Wwox cDNA Clone(NM_001106188.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR005948

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Gene Information

Cat. No. CDFR005948
Description NativeORF clone of Rattus norvegicus WW domain-containing oxidoreductase (Wwox) as transfection-ready DNA NM_001106188.1
Product Type cDAN Clone
Gene Abbr Wwox
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene WWOX
Background This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
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