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Rat Wrap53 cDNA Clone(NM_001007610.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR001622

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Gene Information

Cat. No. CDFR001622
Description NativeORF clone of Rattus norvegicus WD repeat domain 79 (Wdr79) as transfection-ready DNA NM_001007610.1
Product Type cDAN Clone
Gene Abbr Wrap53
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene WRAP53
Background This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
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