Rat Vdr ORF Clone(NM_017058.1)

Name: Rat Vdr ORF Clone(NM_017058.1)
SKU: CDCR378158
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR378158

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Product Information

Gene Information

Cat. No.	CDCR378158
Product Type	ORF Clone
Gene Abbr	Vdr
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	1272 bp
Vector	pCMV6-Entry

Target Gene

VDR

Background

This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]

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