Pages
Products

Rat Usp18 cDNA Clone(NM_001014058.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR003194

Inquire for Price

Product Information

Gene Information

Cat. No. CDFR003194
Description NativeORF clone of Rattus norvegicus ubiquitin specific peptidase 18 (Usp18) as transfection-ready DNA NM_001014058.1
Product Type cDAN Clone
Gene Abbr Usp18
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene USP18
Background The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]
Quick Inquiry

Q & A

Customer Reviews

Ask a Question

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

Write a Review

Write a review of your use of Biogene products and services in your research. Your review can help your fellow researchers make informed purchasing decisions.

Needs improvement

Satisfaction

General satisfaction

Very satisfaction