Transfected Stable Cell Lines
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Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDFR006740
| Cat. No. | CDFR006740 |
| Description | NativeORF clone of Rattus norvegicus unc-45 homolog B (C. elegans) (Unc45b) as transfection-ready DNA NM_001107028.1 |
| Product Type | cDAN Clone |
| Gene Abbr | Unc45b |
| Species | Rat |
| Size | 10 ug |
| Vector | pCMV6Entry |
| Target Gene | UNC45B |
| Background | This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
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