Rat Ube2d1 cDNA Clone(NM_001108530.1)

Name: Rat Ube2d1 cDNA Clone(NM_001108530.1)
SKU: CDFR008142
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR008142

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Product Information

Gene Information

Cat. No.	CDFR008142
Description	NativeORF clone of Rattus norvegicus ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog (yeast) (Ube2d1) as transfection-ready DNA NM_001108530.1
Product Type	cDAN Clone
Gene Abbr	Ube2d1
Species	Rat
Vector	pCMV6Entry

Target Gene

UBE2D1

Background

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

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