Rat Tyms cDNA Clone(NM_019179.1)

Name: Rat Tyms cDNA Clone(NM_019179.1)
SKU: CDFR011477
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR011477

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Product Information

Gene Information

Cat. No.	CDFR011477
Description	NativeORF clone of Rattus norvegicus thymidylate synthetase (Tyms) as transfection-ready DNA NM_019179.1
Product Type	cDAN Clone
Gene Abbr	Tyms
Species	Rat
Vector	pCMV6Entry

Target Gene

TYMS

Background

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]

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