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Rat Tpmt cDNA Clone(NM_001079531.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR005022

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Gene Information

Cat. No. CDFR005022
Description NativeORF clone of Rattus norvegicus thiopurine S-methyltransferase (Tpmt) as transfection-ready DNA NM_001079531.1
Product Type cDAN Clone
Gene Abbr Tpmt
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene TPMT
Background This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
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