Transfected Stable Cell Lines
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Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDFR005022
| Cat. No. | CDFR005022 |
| Description | NativeORF clone of Rattus norvegicus thiopurine S-methyltransferase (Tpmt) as transfection-ready DNA NM_001079531.1 |
| Product Type | cDAN Clone |
| Gene Abbr | Tpmt |
| Species | Rat |
| Size | 10 ug |
| Vector | pCMV6Entry |
| Target Gene | TPMT |
| Background | This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014] |
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