Rat Tpm1 ORF Clone(NM_001034068.1)

Name: Rat Tpm1 ORF Clone(NM_001034068.1)
SKU: CDCR371367
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR371367

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Product Information

Gene Information

Cat. No.	CDCR371367
Product Type	ORF Clone
Gene Abbr	Tpm1
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	864 bp
Vector	pCMV6-Entry

Target Gene

TPM1

Background

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. [provided by RefSeq, Jun 2022]

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