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Rat Tp63 cDNA Clone(NM_001127342.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR009529

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Gene Information

Cat. No. CDFR009529
Description NativeORF clone of Rattus norvegicus tumor protein p73-like (Tp73l), transcript variant 4 as transfection-ready DNA NM_001127342.1
Product Type cDAN Clone
Gene Abbr Tp63
Species Rat
Vector pCMV6Entry
Target Gene TP63
Background This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]
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