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Rat Tk2 cDNA Clone(NM_001106166.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR005925

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Gene Information

Cat. No. CDFR005925
Description NativeORF clone of Rattus norvegicus thymidine kinase 2, mitochondrial (Tk2), nuclear gene encoding mitochondrial protein as transfection-ready DNA NM_001106166.1
Product Type cDAN Clone
Gene Abbr Tk2
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene TK2
Background This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]
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