Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDFR009133
| Cat. No. | CDFR009133 |
| Description | NativeORF clone of Rattus norvegicus T-cell leukemia/lymphoma 1A (Tcl1a) as transfection-ready DNA NM_001109601.1 |
| Product Type | cDAN Clone |
| Gene Abbr | Tcl1a |
| Species | Rat |
| Vector | pCMV6Entry |
| Target Gene | TCL1A |
| Background | Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010] |
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