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Rat Tcl1a cDNA Clone(NM_001109601.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR009133

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Gene Information

Cat. No. CDFR009133
Description NativeORF clone of Rattus norvegicus T-cell leukemia/lymphoma 1A (Tcl1a) as transfection-ready DNA NM_001109601.1
Product Type cDAN Clone
Gene Abbr Tcl1a
Species Rat
Vector pCMV6Entry
Target Gene TCL1A
Background Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
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