Rat Tcf3 ORF Clone(NM_001035237.1)

Name: Rat Tcf3 ORF Clone(NM_001035237.1)
SKU: CDCR371145
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR371145

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Product Information

Gene Information

Cat. No.	CDCR371145
Product Type	ORF Clone
Gene Abbr	Tcf3
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	1941 bp
Vector	pCMV6-Entry

Target Gene

TCF3

Background

This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

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