Rat Syngap1 cDNA Clone(NM_001113409.2)

Name: Rat Syngap1 cDNA Clone(NM_001113409.2)
SKU: CDFR009313
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR009313

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Product Information

Gene Information

Cat. No.	CDFR009313
Description	NativeORF clone of Rattus norvegicus synaptic Ras GTPase activating protein 1 homolog (rat) (Syngap1), transcript variant 2 as transfection-ready DNA NM_001113409.2
Product Type	cDAN Clone
Gene Abbr	Syngap1
Species	Rat
Vector	pCMV6Entry

Target Gene

SYNGAP1

Background

This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

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