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Rat Sptbn2 cDNA Clone(NM_019167.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR011465

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Cat. No. CDFR011465
Description NativeORF clone of Rattus norvegicus spectrin, beta, non-erythrocytic 2 (Sptbn2) as transfection-ready DNA NM_019167.1
Product Type cDAN Clone
Gene Abbr Sptbn2
Species Rat
Vector pCMV6Entry
Target Gene SPTBN2
Background Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009]
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