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Rat Sppl2b cDNA Clone(NM_001014200.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR003313

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Gene Information

Cat. No. CDFR003313
Description NativeORF clone of Rattus norvegicus signal peptide peptidase-like 2B (Sppl2b) as transfection-ready DNA NM_001014200.1
Product Type cDAN Clone
Gene Abbr Sppl2b
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene SPPL2B
Background This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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